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  "name": "OneLongevity Longevity Glossary",
  "description": "Concise, science-based definitions of key terms in longevity medicine, curated by OneLongevity. Free to cite as 'OneLongevity Glossary' (CC BY 4.0).",
  "url": "https://onelongevity.me/glossar",
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  "dateModified": "2026-07-15T16:17:23.182Z",
  "count": 12,
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    {
      "@type": "DefinedTerm",
      "@id": "https://onelongevity.me/glossar#nad",
      "name": "NAD+",
      "description": "Central coenzyme for cellular energy and DNA repair; intracellular levels decline ~50% between age 30 and 70.",
      "alternateName": [
        "Nicotinamide adenine dinucleotide",
        "Coenzym I"
      ],
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      "name": "NMN",
      "description": "Direct NAD+ precursor, used orally or sublingually to raise NAD+ levels.",
      "alternateName": [
        "β-NMN",
        "Nicotinamide mononucleotide"
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      "@type": "DefinedTerm",
      "@id": "https://onelongevity.me/glossar#rapamycin",
      "name": "Rapamycin (Sirolimus)",
      "description": "mTORC1 inhibitor with documented lifespan extension in mice (NIA ITP: 9–26%). Off-label human use in longevity medicine.",
      "alternateName": [
        "Sirolimus",
        "Rapamune"
      ],
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      "name": "Senolytics",
      "description": "Small molecules (e.g. dasatinib+quercetin, fisetin) that selectively clear senescent 'zombie' cells.",
      "subjectOf": "https://onelongevity.me/magazin/senolytika",
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      "@id": "https://onelongevity.me/glossar#autophagy",
      "name": "Autophagy",
      "description": "Cellular self-cleaning process; upregulated by fasting, caloric restriction and rapamycin (Ohsumi, Nobel 2016).",
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      "name": "VO₂max",
      "description": "Maximum oxygen uptake; strongest single mortality predictor. Declines ~10% per decade after age 30 without training.",
      "sameAs": "https://en.wikipedia.org/wiki/VO2_max",
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      "@id": "https://onelongevity.me/glossar#hbot",
      "name": "HBOT",
      "description": "Hyperbaric oxygen therapy: breathing 100% O₂ at 1.5–2.5 ATA. Evidence for wound healing, cognitive recovery; longevity claims investigational.",
      "alternateName": [
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    {
      "@type": "DefinedTerm",
      "@id": "https://onelongevity.me/glossar#telomere",
      "name": "Telomere",
      "description": "Repetitive DNA cap at chromosome ends; shortens with each cell division. Length correlates with biological age.",
      "sameAs": "https://en.wikipedia.org/wiki/Telomere",
      "subjectOf": "https://onelongevity.me/magazin/telomer-test",
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    {
      "@type": "DefinedTerm",
      "@id": "https://onelongevity.me/glossar#epigenetic-age",
      "name": "Epigenetic age",
      "description": "Biological age estimated from DNA-methylation clocks (Horvath, GrimAge, PhenoAge). Predicts mortality better than chronological age.",
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    {
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      "@id": "https://onelongevity.me/glossar#glp1",
      "name": "GLP-1 agonists",
      "description": "Incretin-mimetic drugs (semaglutide/Ozempic, tirzepatide/Mounjaro) for weight loss and metabolic control. Cardio-renal outcome benefits documented.",
      "subjectOf": "https://onelongevity.me/magazin/glp1-ozempic-longevity",
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      "@id": "https://onelongevity.me/glossar#dexa",
      "name": "DEXA scan",
      "description": "Dual-energy X-ray absorptiometry: gold-standard body composition (±1.5%) and bone density (T-/Z-score).",
      "subjectOf": "https://onelongevity.me/magazin/dexa-scan-biohacking",
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      "name": "Hallmarks of Aging",
      "description": "López-Otín et al. (Cell 2023): 12 interconnected drivers of aging (genomic instability, telomere attrition, senescence, mitochondrial dysfunction, etc.). OneLongevity's editorial framework.",
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